TN visa at Detroit-Windsor

Hi everyone, I'm planning on going to the Detroit-Windsor POE to get my TN visa however I also have to go into Detroit to get a drug test completed. My plan is to go get the TN and do the drug test then come back to Canada for a few days (and quarantine) and crossing back for good the following week.

Is that something I am able to do or will I have issues for not completing the full 14 day quarantine? and will I be required to book a hotel if I am going by car?