Apply for Visitor Visa from Canada. Left USA after 16 yrs recently

Hi there, most of my adult life was spent on various visas in the US (F-1 and H1B). We recently relocated to Canada for work and personal reasons (wife is Canadian).
If I apply for a US Visa in the next couple months, am I setting myself up for denial, since I haven't spent much time in Canada and don't have deeper roots here?

I've a house I bought in US, most of my extended family is there and I would love to visit them.